Jurickson Profar had four hits and drove in two runs Wednesday as the San Diego Padres scored six runs in the first two innings against Madison Bumgarner to defeat the visiting Arizona Diamondbacks 10-4 and complete a three-game series sweep.

The Padres, who have won six of seven games this season against the Diamondbacks, scored four in the first and two in the second - although Bumgarner could have escaped trouble in both innings with better defense.

Profar opened the first with a single and moved to second when Jake Cronenworth was hit by a pitch. Bumgarner then struck out Luke Voit and Jorge Alfaro. Ha-Seong Kim followed with a grounder to third that got away from Josh Rojas, but was ruled a hit to load the bases.

Austin Nola put the Padres on the board with a two-run single, while Trent Grisham and Jose Azocar followed with RBI singles to make it 4-0.

Profar again led off the second with a single and moved to second when Cronenworth reached on an error by shortstop Geraldo Perdomo. Voit followed with an RBI single and Cronenworth scored when Alfaro grounded into a double play for a 6-0 advantage.

Arizona cut the lead to 6-1 on Alek Thomas' solo homer off Padres' starter Mike Clevinger leading off the third. It was the rookie's sixth home run of the season.

But Profar had a two-run single in the fifth and Alfaro answered an unearned Diamondbacks run in the top of the sixth with a 430-foot home run off the upper balcony of the Western Metal Supply Co. building in left.

Jose Azocar doubled home the Padres final run with his third hit of the game.

Christian Walker hit his 19th homer of the season for Arizona in the seventh.

Bumgarner (3-7) gave up six runs (four earned) on nine hits and a hit batter with five strikeouts in four innings. Clevinger, who was making his first start since June 5, allowed one run on four hits and two walks with three strikeouts in four innings. Adrian Morejon (1-0) gave up an unearned run in 1 1/3 innings.

Arizona added another unearned run in the ninth as the Padres won despite committing four errors.